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Commercials are everywhere. So are the testimonies of social networks and celebrity rumors: it is said that each moderately famous person who falls a few pounds is in it. In a few years, Ozempic (Semaglutida) has become abbreviation for severe weight loss.
This injectable medicine, the best known medication in a category that includes Wogovy and Rybelsus (both semaglutidos) and Mounjaro and Zepbound (Tirzepatides), has been a so -called game changer for weight control.
If you are looking for help in that area, you have undoubtedly wondered: how much weight can you lose in Ozempic?
The semagglutidas and the IRZEPATIDAS belong to a family of pharmaceutical products known as incredine mimetics, which, among other things, make you feel full faster and longer after eating. They work activating receptors of an intestinal hormone called LPG-1 (peptide similar to glucagon) that helps regulate blood sugar and digestion levels.
“Medicines stimulate the cells of pancreatic islets, where insulin is performed, decelerating the emptying of the stomach,” explains Spencer Kroll MD, Ph.D., FNLA, an internal medicine doctor certified by the board and author of The Ozempic diet. “Medications also inhibit Food haddies and intake. “
He adds: “In patients with type 2 diabetes, there is a deteriorated insulin response to LPG-1.” These medications address this insufficiency, helping to restore adequate pancreatic function.
Due to your body action, these drugs can:
SEMAGLUTID AND TIRZEPATIDA were originally developed as diabetes drugs. From now on, the pinch (semaglutida) and Zepbound (Tirzepatida) are the only ones that are approved by the FDA specifically for weight loss.
The other medications are prescribed “label out of place”, or not as indicated, for weight loss.
In addition to stimulating GLP-1 pancreatic receptors such as the semaglutid, the tirzepatidos such as Mounjaro and Zepbound have an additional mechanism of action: they stimulate GIP receptors (glucose-dependent insulinotropic polypeptide) as well. Both types of incredine receptors are involved in blood sugar control and occur naturally in the intestine.
But it is important to remember that these drugs come with inherent limitations.
“Average weight loss with these medications is close 15 percent of total body weight“, Says Kroll.” That is compared superior to all other known weight loss strategies, where average weight loss is usually 5 percent to 10 percent of total body weight. “
Here is an average weight loss scale in semaglutides based on the initial weight:
But there is no guarantee. Pharmaceutical -assisted weight loss does not have a great sustainability history. And again, this last kind of weight loss medications has not been thoroughly tested in non -diabetics, so it is not clear if weight loss is consistent or lasting, particularly once the medications are suspended.
In addition, to obtain optimal results, weight loss medications are generally prescribed along with a healthy diet and resistance training, which are proven methods of weight loss themselves.
As the side effects are potentially serious and are experienced in some way at a relatively high rate (see below), taking these medications indefinitely is not only expensive but possibly dangerous. In addition, taking a LPG-1 agonist as Ozempic does not address many of the root causes of weight gain, including inactivity and consumption of addictive and poor nutrients Ultra processed foods and sugar.
The new class of weight loss drugs has a series of related consequences that range from common side effects to unknowns about long -term use. Anyone who considers them should discuss potential risks with a doctor before using.
“The most common concern of these medications and their side effects is related to their action on the gastrointestinal tract,” says Kroll. “By stimulating pancreas, sometimes medications can cause pancreatic inflammation or pancreatitis.
“Other common side effects, but less worrying are changes in intestinal habits, manifested as diarrhea or constipation,” says Kroll. “There may also be a sensation of nausea, especially when the medications begin or the dose is adjusted.” These effects occur in up to 50% of users.
Up to 45% of the lost weight As a result of these drugs, they can come from lean mass (muscle), which can have negative effects on metabolic health (for example, slower metabolism) and physical strength.
To protect muscle mass, users must perform resistance training and consume adequate amounts of calories, proteins and micronutrients while using the medication, which can be difficult to achieve with a suppressed appetite.
Some semaglutida users and similar medications have reported “face Ozempic” and “Ozempic rear”, the skin fallen as a result of rapid weight loss.
If you are looking for proven and sustainable weight loss that you do not break it, science has repeatedly discovered that you can expect it from a Well -designed exercise diet and exercise plan.
“The most effective way to lose weight sustainably is through changes in lifestyle. That means a change in the diet and an increase in physical activity, ”says Kroll. “GLP-1 medications may not cause sustained weight loss other than any other type of diet, medication or supplement.”
He warns: “Those patients who have arrested GLP-1 agents have seen weight back. The key to sustained weight loss is the modification of lifestyle, sometimes in combination with these newer and more strongly effective medications. “
The fact is that the pharmacology has not yet improved in the Weight maintenance pillars.
“Sustainable weight loss is generally achieved by creating a Deficiency caloriethat can be achieved by consuming fewer calories than it burns, ”he says Gloria Thumm, MDRegenerative Medicine Physician in Temecula, California.
Some good strategies include:
Another key factor, says Tumbaga, is support. When he works to lose weight, looking for guidance from a health professional, dietaryeither Support groups It can help maintain motivation and responsibility.
It is the type of support you can find in Bodi, with training for all types of Physical levelMore than 1,000 delicious comprehensive foods recipes to help you eat healthy without feeling private and mindsetMotivation classes and communities that help maintain their strong mind and support him on his weight loss trip.